TABLE 1.
Cytokine expression preceding clearance of an HPV infection
| Subject | Visit no. | HPV type cleareda | Result of test
ford:
|
|||
|---|---|---|---|---|---|---|
| IFN-γ | IL-4 | TNF | IL-12 | |||
| a | 15 | MM9 | + | − | + | + |
| b | 12 | Untyp.b | + | − | + | − |
| c | 10 | Untyp. | + | − | + | + |
| d | 10 | 16 | + | − | + | − |
| e | 14 | 58 | + | − | + | − |
| f | 16 | 39 | + | − | + | + |
| g | 11 | Low-risk types,c 56 | + | − | + | + |
a
HPV type which was cleared by the following visit (4 months later).
b
Untyp., HPV positive by generic HPV probe but not positive for any of the types tested.
c
Low-risk types, positive on a probe mix which recognizes four low-risk HPV types (i.e., types 6, 11, 42, and 44).
d
Overall, 100% of these subjects had the Th1 cytokine pattern, defined as the expression of IFN-γ and absence of IL-4 by RT-PCR. Percentages of subjects expressing IFN-γ, IL-4, TNF, and IL-12 were 100, 0, 100, and 57%, respectively. +, positive; −, negative.