TABLE 3.
Cytokine expression in subjects who have previously cleared an HPV infectiona
| Subject | Months since the last positive HPV test | Result of test forb:
|
|||
|---|---|---|---|---|---|
| IFN-γ | IL-4 | TNF | IL-12 | ||
| h | 4 | + | + | + | + |
| i | 4 | + | − | + | + |
| j | 4 | + | + | + | + |
| k | 4 | − | − | + | − |
| l | 8 | + | − | + | + |
| m | 8 | + | + | + | − |
| n | 9 | − | NDc | + | − |
| o | 10 | + | ND | + | − |
| p | 12 | − | + | + | − |
| q | 17 | + | + | − | − |
| r | 17 | − | + | + | + |
| s | 21 | + | − | + | + |
| t | 22 | + | + | + | − |
| u | 39 | + | + | + | + |
| v | 75 | − | + | + | − |
All subjects shown in the table had a history of HPV infection and clearance and were HPV negative at the time of the cytokine assay. In cases where cytokine data was available for more than one HPV-negative visit by a subject, only the first visit with cytokine data was included in this cross-sectional analysis.
Overall, 23% of these subjects had the Th1 cytokine pattern, defined as the expression of IFN-γ and absence of IL-4 by RT-PCR. Due to incomplete data, subjects n and o were not included in determining the percentage of subjects with Th1 pattern. Percentages of subjects expressing IFN-γ, IL-4, TNF, and IL-12 were 67, 69, 93, and 47%, respectively.
ND, not determined.