TABLE 4.
Cytokine expression in HPV-positive subjectsa
| Subject | Minimum no. of months with positive HPV testb | HPV type | Result of
test forf:
|
|||
|---|---|---|---|---|---|---|
| IFN-γ | IL-4 | TNF | IL-12 | |||
| w | 0 (New)c | MM8 | + | + | + | + |
| x | 0 (New) | Untyp.e | + | + | + | + |
| y | 0 (New) | Untyp. | + | − | + | − |
| z | 0 (New) | MM8 | + | + | + | − |
| aa | 0 (New) | 18 | + | − | + | − |
| bb | 0 (New) | Untyp. | − | − | + | − |
| cc | 0 (New) | MM8 | + | − | + | + |
| dd | 4 | 16 | + | − | + | − |
| ee | 9 | 16 | + | − | + | + |
| ff | 12 | 16 | − | − | − | − |
| gg | 20 | 16 | + | − | + | − |
| hh | 22 | 58 | − | − | + | − |
| ii | 22 | 16 | + | − | + | + |
| jj | 46 | 31/33/35d | + | − | + | + |
| kk | 49 | 16 | + | − | + | + |
In cases where cytokine data was available for more than one visit by a subject, only the first visit with cytokine data was included in this cross-sectional analysis.
Since HPV infection was acquired at an indeterminate time prior to the first positive study visit, the actual duration of infection may be longer.
New, a newly positive test at the study visit shown.
Positive on a probe mix which recognizes these three types.
Untyp., HPV positive by generic HPV probe but not positive for any of the types tested.
Overall, 60% of these subjects had the Th1 cytokine pattern, defined as the expression of IFN-γ and absence of IL-4 by RT-PCR. Percentages of subjects expressing IFN-γ, IL-4, TNF, and IL-12 were 80, 20, 93, and 47%, respectively.