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. 2022 Oct 17;13:6123. doi: 10.1038/s41467-022-33860-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Sequence alignment of V_H and V_L iGL precursors of BG24 (VH1-2*02 and VL2-11*01), BG24_iGL-CDR3iGL, BG24_iGL-CDR3mat, and BG24_mat. CDRs are highlighted in yellow. Asterisks (*) indicate residue differences between mature and iGL CDR3s. Underlined CDRL1 indicates sequence used for the CDRL1 in the BG24_CDRL1-iGL construct. b, c Side and top-down (inset) views of cryo-EM density of BG24_iGL-CDR3iGL-GT1-10-1074 (b) and BG24_iGL-CDR3mat-GT1-10-1074 (c) Highlighted in colors include: gp120 subunits (light gray), gp41 (dark gray), BG24_iGL-CDR3iGL VH (bright pink) and VL (light pink) domains, BG24_iGL-CDR3mat VH (dark purple) and VL (light purple) domains, and 10-1074 VH (dark brown) and VL (light brown) domains.