Table 1.
Baseline demographics of the patients.
| Maintained weight* (n = 161, 74.9%) | Reduced weight** (n = 54, 25.1%) | P-value | |
|---|---|---|---|
| Age (years) | 71.2 ± 7.2 | 73.8 ± 7.7 | 0.032 |
| Sex | |||
| Male | 134 (83.2%) | 41 (75.9%) | 0.233 |
| Female | 27 (16.8%) | 13 (24.1%) | |
| BMI (kg/m2) | 24.4 ± 2.9 | 23.0 ± 2.9 | 0.002 |
| Baseline body weight (kg) | 65.3 ± 9.3 | 60.1 ± 9.0 | < 0.001 |
| Smoking history | |||
| Never smoker | 35 (21.7%) | 11 (20.4%) | 0.692 |
| Ever smoker | 126 (78.3%) | 43 (79.6%) | |
| Comorbidities | |||
| Hypertension | 48 (29.8%) | 12 (22.2%) | 0.282 |
| Diabetes mellitus | 41 (25.5%) | 12 (22.2%) | 0.635 |
| COPD | 21 (13.0%) | 2 (3.7%) | 0.055 |
| Malignancy | 23 (14.3%) | 3 (5.6%) | 0.089 |
| Pulmonary function test | |||
| FVC (% of predicted) | 81.1 ± 15.5 | 71.1 ± 16.8 | < 0.001 |
| DLCO (% of predicted) | 72.0 ± 20.5 | 62.3 ± 20.7 | 0.004 |
| Pirfenidone treatment | |||
| Dose adjustment | 56 (34.8%) | 19 (35.2%) | 0.957 |
Data are expressed as mean ± standard deviation or counts (%).
BMI body mass index, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, COPD chronic obstructive pulmonary disease.
*Maintained weight group is weight gain or weight loss < 5%/year, **Reduced weight group is weight loss ≥ 5%/year.