Table 4.
All-cause mortality from time since IPF diagnosis, for the significant baseline predictors at diagnosis as estimated by the Cox proportional-hazards ratio model.
| Characteristic | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Male sex | 1.097 | 0.692–1.739 | 0.6949 | – | – | – |
| Age | 1.057 | 1.030–1.085 | < 0.001 | 1.054 | 1.029–1.081 | < 0.001 |
| Smoking | ||||||
| Ever smoking | 0.820 | 0.543–1.237 | 0.3441 | – | – | – |
| Baseline BMI (kg/m2) | 0.958 | 0.902–1.018 | 0.1694 | – | – | – |
| Reduced body weight | 3.270 | 2.254–4.743 | < 0.001 | 2.358 | 1.572–3.537 | < 0.001 |
| Baseline PFT | ||||||
| FVC (% of predicted) | 0.976 | 0.965–0.988 | < 0.001 | 0.992 | 0.978–1.006 | 0.2682 |
| DLCO (% of predicted) | 0.974 | 0.965–0.983 | < 0.001 | 0.980 | 0.968–0.991 | < 0.001 |
BMI body mass index, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, HR Hazard Ratio, CI confidence Interval.