TABLE 1.

Percentage of isolates in Mali with mutant variants within known Plasmodium falciparum drug-resistance-associated genes. Only variants found in at least 2 percent of any of the geo-temporal populations are presented.

Gene	Mutation	Position	Bamako	Bougoula	Dangassa	Faladje	Kenieroba	Kolle	Nioro
CRT	K76T	Pf3D7_07_v3.403625	64	27	50	37	48	57	46
	A220S	Pf3D7_07_v3.404407	66	29	53	38	23	59	49
	Q271E	Pf3D7_07_v3.404836	66	28	53	38	50	62	48
	N326S	Pf3D7_07_v3.405362	2	3	1	1	2	0	0
	I356T	Pf3D7_07_v3.405600	39	12	39	22	39	24	41
	R371I	Pf3D7_07_v3.405838	65	0	0	48	0	61	0
DHFR	N51I	Pf3D7_04_v3.748239	63	77	76	72	76	51	70
	C59R	Pf3D7_04_v3.748262	68	83	79	73	80	57	72
	S108N	Pf3D7_04_v3.748410	69	85	83	72	81	57	72
DHPS	E189Q	Pf3D7_08_v3.548940	1	1	2	1	1	3	1
	I431V	Pf3D7_08_v3.549666	1	2	0	0	0	0	1
	S436A	Pf3D7_08_v3.549681	57	58	46	53	42	65	56
	G437A	Pf3D7_08_v3.549685	47	35	30	48	37	63	55
	A613S	Pf3D7_08_v3.550212	7	8	9	6	7	10	3
MDR1	N86Y	Pf3D7_05_v3.958145	22	11	11	14	17	29	12
	Y184F	Pf3D7_05_v3.958440	66	58	63	62	68	71	60
	P203S	Pf3D7_05_v3.958496	1	2	1	0	0	1	1
	N504K	Pf3D7_05_v3.959401	4	0	0	4	0	1	0
	F938Y	Pf3D7_05_v3.960702	4	7	3	2	1	0	0
	D1246Y	Pf3D7_05_v3.961625	1	3	1	2	1	2	1
MDR2	M1019K	Pf3D7_14_v3.1954620	0	0	0	3	0	0	0
	I492V	Pf3D7_14_v3.1956202	52	62	51	53	51	60	44
	F423Y	Pf3D7_14_v3.1956408	76	75	64	66	63	75	57
	K253T	Pf3D7_14_v3.1956918	2	1	4	4	1	1	6
	V250I	Pf3D7_14_v3.1956928	3	9	4	3	5	3	3
	S208N	Pf3D7_14_v3.1957053	89	83	87	83	87	96	85
	R176L	Pf3D7_14_v3.1957149	8	0	0	9	0	9	0
	T23M	Pf3D7_14_v3.1957608	1	2	2	4	1	1	3
K13	R255K	Pf3D7_13_v3.1726234	2	0	1	2	2	5	5
	K189N	Pf3D7_13_v3.1726431	5	2	5	2	6	9	2
	K189T	Pf3D7_13_v3.1726432	51	50	53	54	54	52	43
	G112E	Pf3D7_13_v3.1726663	2	0	1	0	1	0	4