Changes in liver biomarkers.
Mean (SEM) levels from baseline to Day 84 and percent reduction on Day 28 in (A–C) GGT, (D–F) ALP, (G-I) ALT, and (J–L) total bilirubin. Patients who achieved GGT <65 U/L, ALP <1.67× ULN (<174 U/L), ALT <45 U/L, or total bilirubin <0.6× ULN (12.6 μmol/L) by Day 28 were considered to have normalised response. ALP, alkaline phosphatase; ALT, alanine aminotransferase; GGT, γ-glutamyl transferase; ULN, upper limit of normal.