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FOXP1 role in T-cell quiescence. In naïve T-cells FOXP1 inhibits MAPK and PI3K pathways. FOXP1 also represses IL-7Ra expression, preventing IL-7-driven antigen-independent proliferation. FOXP1-deficient naïve T-cells demonstrate activated surface phenotype, PI3K pathway activation in response to IL-7, and the higher expression of E2F factors and their target genes (MCM5, CDK1, PCNA).
