Fig. 3.

An exemplary whole slide image explains the morphology of the lymph node, where the region dense with nuclei is packed within a capsule and the inner area is called the subcapsular sinus. From the diagnostic point of view, the quantification of positive lymph nodes (i.e. visual identification of tumor cells) in TNM (Tumor , Lymph Nodes , Metastases ) staging is an important prognostic-marker and this visual search for tumor cells starts at the capsular region. The outer region (outward from the capsule) mostly contains fatty tissue, blood vessels, and muscle tissue; and is similar in stain color and morphology to the capsule.