TABLE 4.
Pharmacokinetic parameters of Rufi-NC-RXG, Rufi-NC-Susp, Rufi-Susp, and Rufi-RXG in brain and plasma following intranasal administration at a drug dose of 1 mg/kg in male Wistrar rats.
| Matrix | Parameter | Units | Formulations | |||
|---|---|---|---|---|---|---|
| Rufi-NC-Susp | Rufi-NC-RXG | Rufi-Susp | Rufi-RXG | |||
| Plasma | AUC0→tlast | Min ×( µg/ml) | 258.2 ± 68.6 | 192.3 ± 59.5 | 200.75 ± 74.4 | 53.34 ± 10.4 |
| Cmax | µg/mL | 0.92 ± 0.17 | 0.76 ± 0.17 | 1.16 ± 0.53 | 0.32 ± 0.02 | |
| Tmax | min | 30–45 | 60 | 120 | 120 | |
| MRT | min | 223.8 ± 9.0 | 177.4 ± 16.4 | 147.4 ± 9.4 | 136.3 ± 12.2 | |
| Brain | AUC0→tlast | Min × (µg/g) | 340.7 | 471.3 | 104.28 | 201.8 |
| Cmax | µg/g | 1.31 ± 0.19 | 1.81 ± 0.3 | 0.79 ± 0.11 | 1.48 ± 0.09 | |
| Tmax | min | 60 | 60 | 60 | 60 | |
| %DTE | 373.16 | 693.1 | 146.8 | 1069.9 | ||
| %DTP | 73.3 | 85.5 | 31.9 | 90.6 | ||
Note: Data is represented as “mean ± SD” of n = 4 observations.