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. 2022 Oct 4;14:949361. doi: 10.3389/fnagi.2022.949361

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Copyright © 2022 Shade, Ross and Van Bockstaele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cannabinoids Prevent Hyper-Activation of Stress-Integrative Circuitry, Protecting Cortical Network Integrity, Reducing Cellular Stress, Inflammation, Reduce Behavioral Symptoms and Improve Cognitive Function. (A) Cannabinoid-induced reversal of stress-induced dendritic retraction in cortical areas. (B) Cannabinoid-mediated engagement/activation of GABAergic interneurons of the BLA- reduces central drive to the CeA. (C) Cannabinoid-mediated reduction in central drive of the CeA results in downstream reductions in excitatory input to LC neurons, protecting them from consequences of hyperactivation. (D) Cannabinoids (including CBD) protect neurons from (D) Alzheimer’s Neuropathology Neuropathology, and (E) excitotoxicity and/or hyperactivity via Gαi signaling (D,E) are depicted in greater detail in Figure 6.