TABLE 1.
Role of WNT components in neurogenesis.
| WNT pathway component | Role in neurogenesis | Citation |
| WNT3a | Essential for normal developmental neurogenesis. It also activates the transition of NSCs from proliferation to differentiation | Lee et al., 2000; Kuwabara et al., 2009 |
| WNT5a | By activating the non-canonical WNT signaling pathways (WNT/JNK and WNT/CaMKII) WNT5a promotes neuronal differentiation of progenitor cells and stimulates dendritic development of adult-born neurons without affecting their fate-commitment and neuronal migration | Vivancos et al., 2009; Arredondo et al., 2020a |
| WNT7a | Regulates NSCs’ self-renewal and proliferation as well as differentiation and maturation | Qu et al., 2013; Fernando et al., 2014; Wang et al., 2018 |
| FZD1 | Regulates adult hippocampal neurogenesis at the neuronal differentiation level | Mardones et al., 2016 |
| FZD3 | One of the core PCP proteins that play roles in regulating granule cell morphogenesis, dendritic patterning, axonal tract development, and neuronal migration | Wang et al., 2002; Qu et al., 2010a; Feng et al., 2012a; Schafer et al., 2015 |
| FZD6 | Plays a role in neural tube closure along with FZD3 | Wang et al., 2006 |
| FZD7 | Essential to maintain pluripotency in embryonic stem cells and extensively studied for its role in tumorigenesis | Fernandez et al., 2014 |
| sFRP3 | WNT inhibitor that is highly expressed by adult dentate gyrus granule neurons and regulates multiple phases of adult hippocampal neurogenesis | Jang et al., 2013; Sun et al., 2015 |
| Ngn2 | Transcription factor involved in the commitment and differentiation of neuronal progenitors during postnatal olfactory bulb neurogenesis and used to generate functional neurons from human pluripotent stem cells | Roybon et al., 2009; Zhang et al., 2013 |
| NeuroD1 | Essential for the survival and maturation of adult-born neurons facilitated by SOX2 and TCF/LEF regulatory elements on its promoter region | Gao et al., 2009; Kuwabara et al., 2009 |
| Prox1 | A transcription repressor regulates the balance between self-renewal and neuronal differentiation of the neuronal progenitor cells | Kaltezioti et al., 2010; Foskolou et al., 2013 |
| ATP6AP2 | A core adapter protein involved in WNT/β-catenin and WNT/PCP signaling pathways. Plays a role in determining the NSCs fate and morphogenesis during adult neurogenesis | Schafer et al., 2015 |