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. 2022 Oct 4;16:1012812. doi: 10.3389/fnins.2022.1012812

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Copyright © 2022 Challa, Nalamolu, Fornal, Wang, Martin, Olson, Ujjainwala, Pinson, Klopfenstein and Veeravalli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M12sh treatment is effective in reducing MMP-12 expression in vivo. The column scatter plots show the quantified mRNA expression of MMP-12 (expressed as fold change over sham) on post-reperfusion days 1 and 3 in the contralateral (Contra) and ipsilateral (Ipsi) brain hemispheres of male rats subjected to 2-h transient focal cerebral ischemia. Statistical analysis: Two-way ANOVA followed by Sidak’s/Tukey’s multiple comparisons tests. ⁺p < 0.05 vs. Contralateral brain hemisphere (same experimental group). *p < 0.05 vs. Sham (same brain hemisphere). ^δ p < 0.05 vs. Ischemia (Untreated) group (same brain hemisphere).