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. 2022 Oct 4;16:1012812. doi: 10.3389/fnins.2022.1012812

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Copyright © 2022 Challa, Nalamolu, Fornal, Wang, Martin, Olson, Ujjainwala, Pinson, Klopfenstein and Veeravalli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of a single-dose M12sh treatment given at different times after reperfusion on post-stroke neurological and functional recovery. Following 2-h focal cerebral ischemia, both male (A) and female (B) rats subjected to treatments with either SVsh (immediately after reperfusion) or M12sh (immediately after reperfusion, 3-h after reperfusion, or 6-h after reperfusion) were evaluated for assessment of various neurological and functional tests at baseline (bl) and at regular intervals (days 1, 3, 5, and 7). Post-ischemic neurological and functional deficits were assessed by the mNSS assessment, the accelerating Rotarod performance, and the modified adhesive removal tests. n = 23–28 males and 11–13 females (SVsh group), 26–28 males and 20–22 females (M12sh-IAR group), 10-12 males (M12sh-3hAR group), and 12 males (M12sh-6hAR group) for the various tests. Statistical analysis: Two-way repeated-measures ANOVA followed by Dunnett’s/Sidak’s multiple comparisons tests. *p < 0.05 vs. SVsh (respective post-reperfusion day).