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. 2022 Oct 4;16:1012812. doi: 10.3389/fnins.2022.1012812

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Copyright © 2022 Challa, Nalamolu, Fornal, Wang, Martin, Olson, Ujjainwala, Pinson, Klopfenstein and Veeravalli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of acute vs. chronic suppression of MMP-12 on long-term neurological recovery after an ischemic stroke. Following 2-h focal cerebral ischemia, male (A) and female (B) rats subjected to treatments with either single-dose (SD) SVsh/M12sh (immediately after reperfusion) or repeated-dose (RD) M12sh (immediately after reperfusion and on post-reperfusion days 7 and 14) were evaluated for assessment of neurological and functional tests at baseline (bl) and at regular intervals (days 1, 7, 14, and 21). Post-ischemic neurological and functional deficits were assessed by the mNSS assessment, the beam walk, the accelerating Rotarod performance, and the modified adhesive removal tests. n = 8–12 males and 10–12 females (SVsh group), 10–12 males and 9–12 females (M12sh-SD group), and 9–10 males and 10 females (M12sh-RD group) for the different tests. Statistical analysis: Two-way repeated-measures ANOVA followed by Tukey’s multiple comparisons tests. *p < 0.05 vs. SVsh (respective post-reperfusion day).