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. 2022 Oct 14;222(1):e202112108. doi: 10.1083/jcb.202112108

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© 2022 O'Brien et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Loss of the GARP complex also impairs class I da neuron dendrite remodeling. (A) Representative maximum intensity z-projections of c1da neurons from +/+ (UAS-CD4-tdTomato/+; Smid^C161 Gal4/+), Vps50^KO/KO (Vps50^KO, UAS-CD4-tdTomato/Vps50^KO; Smid^C161 Gal4/+), Vps54^KO/KO (Vps54^KO, UAS-CD4-tdTomato/Vps54^KO; Smid^C161 Gal4/+), and Vps54^KO/KO, Smid161>Vps54 (Vps54^KO, UAS-CD4-tdTomato/Vps54^KO; Smid^C161 Gal4/UAS-Vps54) pharate adults (0–8 h after eclosion). Yellow arrows point to the soma. Scale bar = 25 μm. (B) Quantification of total dendrite length of adult c1da neurons. *P = 0.0222, ****P < 0.0001, n.s. P > 0.16. (C) Quantification of larval c1da neurons (96 h AEL) labeled with Gal4²²¹>UAS-CD4-tdGFP, all comparisons n.s. P > 0.78. Both B and C were analyzed by one-way ANOVA with Tukey’s post-test. Data presented as mean ± SD. N = 10 independent neurons/genotype. Samples were collected from at least three independent experiments.