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. 2022 Oct 4;12:1002589. doi: 10.3389/fonc.2022.1002589

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Copyright © 2022 Bian, Wang, Yu, Fu, Zhang, Zhu and Lv

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear discrimination analysis effect size (LEfSe) and linear discriminant analysis (LDA) revealed differences in taxonomic composition in tumor models when compared with HCs, and changes in intestinal microflora composition in tumor models before and after transcatheter arterial chemoembolization (TACE). (A) LDA scores showing differences in models (red) and HCs (green). (B) A cladogram showing taxonomic compositions in models (red) and HCs (green). (C) Bacterial levels in models underwent TACE at different time points and HCs in LDA scores. (D) A cladogram showing different taxonomic compositions in models at different time points and HCs. One day after TACE (red), 5 days after TACE (green), 10 days after TACE (blue), and HCs (purple). (E) Principal component analysis (PCA) of intestinal flora in animals undergoing TACE at indicated time points and HCs. (F) Bacterial diversity analyses in groups undergoing treatment. **p <0.01; *p < 0.05.