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. 2022 Oct 4;12:1002589. doi: 10.3389/fonc.2022.1002589

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Copyright © 2022 Bian, Wang, Yu, Fu, Zhang, Zhu and Lv

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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At 1, 5, and 10 days post-TACE, at each time point, animals were sacrificed with a pentobarbital overdose. (A) Histological H&E staining in tumor tissue (magnification ×200); IHC staining of TLR4, p-STAT3, COX-2, and TUNEL in tumors (magnification ×200). (B) Quantitative PCR (qPCR) was used to detect TLR4 and COX-2 mRNA levels in tissue. Data are represented as the mean ± standard deviation (SD). ^∗∗∗ p < 0.001. (C) Western blotting of tumor tissues.