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Human PDE families.
| PDE families | Gene | Feature |
| PDE1 | PDE1A | Calcium/calmodulin regulated |
| PDE1B | ||
| PDE1C | ||
| PDE2 | cGMP and cAMP specific | |
| PDE3 | PDE3A | cGMP inhibited |
| PDE3B | ||
| PDE4 | PDE4A | cAMP specific |
| PDE4B | ||
| PDE4C | ||
| PDE4D | ||
| PDE5 | PDE5A | cGMP specific |
| PDE6 | PDE6A | Photoreceptor |
| PDE6B | ||
| PDE6C | ||
| PDE7 | PDE7A | Rolipram insensitive |
| PDE7B | ||
| PDE8 | PDE8A | cAMP specific |
| PDE8B | ||
| PDE9 | PDE9A | cGMP specific |
| PDE10 | PDE10A | cAMP inhibited, dual substrate |
| PDE11 | PDE11A | Dual substrate |
