Table 1.
Antihypertensive effects of T-RDN or A-RDN in different animal models
| Blood pressure | |||
|---|---|---|---|
| Animal Model | T-RDN | A-RDN | References |
| SHR | ↓ | → (DR) | Can J Physiol Pharmacol 1980;58:1384–1388 |
| ↓ | Am J Physiol 1982;243:H284–8 | ||
| ↓ | Can J Physiol Pharmacol 1987;65:1548–1558 | ||
| ↓ | Clin Exp Pharmacol Physiol 1995;22:512–517 | ||
| ↓ | J Hypertension 2005;23:851–859 | ||
| ↓ | Am J Physiol Regul Integr Comp Physiol 2006;290:R341–R344 | ||
| SHR-Salt | ↓ | ? | Hypertension 1993;22:1–8 |
| SHRSP | ↓ | ? | Compr Physiol 2017; 7:263–320 |
| SHRSP-Salt | ↓ | ? | J Am Heart Assoc 2013;2:e000375 |
| SHRcp | ↓ | ? | J Am Heart Assoc 2013;2:e000197 |
| Dahl SS (Rat) | ↓ | → | Hypertension 2013;61:806–811 |
| Am J Physiol Regul Integr Comp Physiol 2016;310:R262-R267 | |||
| DOCA-Salt (Rat) | ↓ | ↓ | Am J Physiol Regul Integr Comp Physiol 2015;308:R112-R122 |
| Hypertension 2016;68:1415–1423 | |||
| AngII-Salt (Rat) | → | → | Physiol Rep 2018;6:e13602 |
| AngII-Salt (Rat) | ↓ | ? | Clin Exp Pharmacol Phys 2006;33:1225–1230 |
| AngII-Salt (Mouse) | ↓ | → | Circ Res 2015;117:547–557 |
| AngII(ICV)-Salt (Rat) | ↓ | ? | Hypertension 1997;30:331–336 |
| Obesity HT (Mouse) | ↓ | ? | Hypertension 2016;68:929–936 |
| Obesity HT (Dog) | ↓ | ? | Hypertension 2012;59:331–338 |
| CKD HT (5/6 nephrectomy Rat) | ↓ | J Hypertens 2020;38:765–773 | |
| CKD HT (2K1C Rat) | ↓ | ↓ | Auton Neurosci 2017;208:43–50 |
| Pflugers Arch 2020;472:325–334 | |||
| CKD HT (2K1C Mouse) | ↓ | ↓ | J Neurophysiol 2019;122:358–367 |
| SAS HT (Mouse) | ↓ | ? | SciRep 2018;8:17926 |
↓: depressor effect; →: no effect; ?: untested;. T-RDN: total renal denervation; A-RDN: afferent renal denervation; DR: dorsal rhizotomy; SHR: spontaneously hypertensive rat; SHRSP: stroke-prone SHR; SHRcp: SHR/NDmcr-cp(+/+) rat; Dahl SS: Dahl salt-sensitive rat; DOCA: deoxycorticosterone acetate; Ang II: angiotensin II; ICV: intracerebroventricular injection; HT: hypertension; CKD: chronic kidney disease; 2K1C: 2 kidney 1 clip model; SAS: sleep apnea syndrome.