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. 2022 Oct 30;28(4):693–705. doi: 10.5056/jnm21198

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© 2022 The Korean Society of Neurogastroenterology and Motility

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Suppression of peak frequency (PF) after the administration of 5°C saline in rats. (A) Decreased ratio of PF in high-amplitude pressure following the administration of 5°C saline. To quantify the decrease in high-amplitude pressure induced by 5°C saline, the ratio of contraction frequency before and after administration with a length of more than 8 mm was calculated as the %PF. *P < 0.05 vs room temperature. (B) The area under the curve (AUC) at high-amplitude pressure with 5°C saline. The AUC was calculated before and after drug administration using the lowest intraluminal pressure value as the baseline. There were no significant differences among the 3 groups. (C) The results of the peak pressure amplitude (PPA) at high-amplitude pressure with 5°C saline. The difference between PPA and the lowest intraluminal pressure was defined as PPA, and the ratio of PPA before and after medication was calculated as % PPA. There was no significant difference among the 3 groups (n = 5).