Table 2.
Selective Short Chain Fatty Acid Receptor Agonists Involved in Irritable Bowel Syndrome
| Agonist | Receptor | Function | Model | Refs |
|---|---|---|---|---|
| AR420626 | GPR41 | Stimulate anion secretion, suppress neural activity, and inhibit muscle contractions | Rat | 66, 99 |
| 4-CMTB | GPR43 | Stimulate anion secretion | Rat | 99 |
| AZ1729 | GPR43 | Activated and desensitize of neutrophils | Human neutrophil | 101 |
| phenylacetamide-1 | GPR43 | Modulate the intestinal mucosa protection | Mice | 102 |
| Compound 1 | GPR43 | Slow intestinal transit | Mice | 71 |
| Compound 58 | GPR43 | Activate and desensitize of neutrophils | Human neutrophil | 101 |
| Compound 110 | GPR43 | Attenuate intestinal inflammation | Mice | 100 |
| Compound 187 | GPR43 | Attenuate intestinal inflammation | Mice | 100 |
GPR, G protein coupled receptors.