TABLE 3.

Cox proportional analysis for clinical outcomes.

	Univariate			Model 1			Model 2
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Clinical characteristics
Charlson Comorbidity Index	1.186	0.944–1.49	0.144
AF	2.362	1.300–4.290	0.005	1.156	0.450–2.974	0.763	0.859	0.375–1.967	0.719
MV characteristics
EROA, cm2	1.049	1.029–1.070	<0.001
MR volume, ml	1.037	1.023–1.052	<0.001	1.022	1.006–1.038	0.006
MDPG, mmHg	1.099	0.978–1.235	0.114
Chamber characteristics
LVESV, ml	1.011	1.002–1.020	0.015	1.005	0.993–1.018	0.408
LVEF, %	0.983	0.953–1.014	0.276
LA volume index, ml/m2	1.013	1.007–1.018	<0.001	1.006	0.997–1.015	0.173	1.005	0.997–1.013	0.236
LV GLS, %	1.020	0.997–1.077	0.469
LA strain, %	0.955	0.926–0.985	0.003	0.993	0.945–1.043	0.765
MR volume/LA strain, ml/%	1.348	1.210–1.502	<0.001				1.269	1.109–1.452	<0.001
PASP, mmHg	1.065	1.042–1.088	<0.001	1.034	1.005–1.063	0.020	1.040	1.014–1.066	0.002

AF, atrial fibrillation; EROA, effective regurgitant orifice area; MR, mitral regurgitation; MDPG, mean diastolic pressure gradient; LVESV, left ventricular end-systolic volume; LVEF, left ventricular ejection fraction; LA, left atrial; LV GLS, left ventricular global longitudinal strain; PASP, pulmonary artery systolic pressure.