Table 3.
Brain regions with ALFF differences in ECS and HCs and in ECS cognitive subtypes.
| Brain regions | Cluster size | Peak coordinate (mm)a | Peak t-value | |||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| ECS > HC | Caudate L | 98 | −9 | 9 | 0 | 5.0849 |
| Thalamus B | 54 | −9 | −6 | 9 | 4.7638 | |
| ECS < HC | MPFC B | 49 | 3 | 48 | −24 | −4.4362 |
| PCC/PCu B | 100 | 3 | −54 | 21 | −4.5327 | |
| SI > MI | PreCG L | 47 | −56 | 5 | 19 | 4.9245 |
| SI < MI | PCC/PCu L | 142 | −6 | −57 | 26 | −5.488 |
SI and MI represent the two cognitive subtypes in ECS.
a
Peak coordinate refers to the peak voxel location of the significant cluster in the Montreal Neurological Institute space.
ALFF, amplitude of low-frequency fluctuations; ECS, early course schizophrenia; SI, severely impaired subtype; MI, moderately impaired subtype; HC, healthy control; MPFC, medial prefrontal cortex; PCC/PCu, posterior cingulate cortex/precuneus; PreCG, precentral gyrus; L, left; B, bilateral.