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. 2022 Sep;10(18):976. doi: 10.21037/atm-22-3912

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Graphical abstract of the experimental design. hUC-MSCs-Exos attenuated the progression of OA and prevented severe damage to the knee articular cartilage in the rat OA model. hUC-MSCs-Exos promote chondrocytes proliferation and migration and inhibit chondrocytes apoptosis. hUC-MSCs-Exos reversed IL-1β-induced injury in vitro. hUC-MSCs-Exos could inhibit the secretion of pro-inflammatory factors, promote the expression of anti-inflammatory factors, and regulate the polarization of macrophages. hUC-MSCs-Exos, hUC-MSCs-derived exosomes; hUC, human umbilical cord; MSC, mesenchymal stem cell; OA, osteoarthritis; IL-1β, interleukin 1 beta.