Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep;10(18):985. doi: 10.21037/atm-22-4082

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

PMC Copyright notice

Experimental design for CBD and MA treatments in rats. (A) Chemical structure of MA. (B) Chemical structure of CBD. (C) Experimental protocols. Acclimation phase (days 1–3). Drug administration was once a day over 4 weeks (days 4–31). Rats in the MA group received MA (10 mg/kg) by IP injection. The CBD₄₀ + MA group and the CBD₈₀ + MA group rats received MA (10 mg/kg) following 1 h of CBD treatment (40 or 80 mg/kg, IP). The control group rats received saline solution (containing 5% DMSO +5% Tween-80, 10 mL/kg, IP). The rats in CBD₈₀ group received CBD only (80 mg/kg, IP). On day 32, all the rats were sacrificed for the collection of hearts and blood for further analysis. CBD, cannabidiol; MA, methamphetamine; IP, intraperitoneal; DMSO, dimethyl sulfoxide; Tween-80, polysorbate 80.