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. 2022 Sep;10(18):1014. doi: 10.21037/atm-22-4267

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TGF-β1/EGFR AKT signaling pathway is involved in ADAMTS6-mediated EMT of ovarian cancer cells A2780 and A2780/DDP. (A) Overexpression of ADAMTS6 affects TGF-β1 expression in A2780 and A2780/DDP cells and the EGFR-AKT signaling pathway. The expression of pEGFR/EGFR, pAKT/AKT protein, EMT-related molecules SNAIL1 and ZEB1, and mesothelial marker Vimentin. (B) Schematic diagram of the relationship between CSCs, EMT, and tumor biological behavior. CSCs, cancer stem cells; DDP, cis-diamminedichloroplatinum; EMT, epithelial-mesenchymal transition; OE, overexpression; MDR, multidrug resistance; pEGFR, phosphorylated EGFR; pAKT, phosphorylated AKT.