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. 2022 Sep;10(18):1014. doi: 10.21037/atm-22-4267

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Effects of CD163⁺ TAMs on the proliferation of A2780 and A2780/DDP cells following CIS administration. (A,B) IC50 of A2780 and A2780/DDP cells detected using the MTS assay before and after co-culture with CD163⁺ TAMs (M2). (C) Statistical analysis graph showing that the IC50 of cisplatin in A2780 and A2780/DDP cells increased by 3.1 and 1.4 times, respectively, after co-culture, and the difference was statistically significant (n=6). *, P<0.05; **, P<0.01; ***, P<0.001. CIS, cisplatin; DDP, cis-diamminedichloroplatinum; IC50, half maximal inhibitory concentration; OD, optical density; TAMs, tumor-associated macrophages.