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. 2022 Sep;10(18):1014. doi: 10.21037/atm-22-4267

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CD163⁺ TAMs exosomes can promote the adhesion and migration of EOC cells. (A,B) After the addition of CD163⁺ TAMs (M2 exo), the adhesion ability increased, and DDP administration decreased the cell adhesion. The two kinds of joint treatments had an offset effect, and the overall adhesion of A2780/DDP cells was higher than that of the parental strain. All the results were time dependent. Crystal violet staining, 200×. (C) The two kinds of joint treatments had an offset effect, and the overall adhesion of A2780/DDP cells was higher than that of the parental strain. Crystal violet staining, 400×. All the results were time dependent, and the difference was statistically significant (M2 exo 100 µg, n=3). *, P<0.05; **, P<0.01; ***, P<0.001. DDP, cis-diamminedichloroplatinum; exo, exosomes; EOC, epithelial ovarian cancer; TAMs, tumor-associated macrophages.