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CD163+ TAMs exosomes (M2 exo) inhibited ADAMTS6 expression, activated the phosphorylation of its downstream molecule AKT, and increased the expression of EMT transcription factors ZEB1, SNAIL1, and VIM, and the difference was statistically significant (exo 100 µg, n=6). *, P<0.05; **, P<0.01; ***, P<0.001. DDP, cis-diamminedichloroplatinum; exo, exosomes; EMT, epithelial-mesenchymal transition; TAMs, tumor-associated macrophages; VIM, Vimentin.
