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. 2022 Oct 17;10(5):e003010. doi: 10.1136/bmjdrc-2022-003010

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Changes after 24 weeks of lifestyle intervention in body composition, biochemical (A) and dietary traits (B). Changes are displayed as Log2 fold change and SE. The intervention effectively reduced fasting glucose, HbA1c, weight, waist circumference, and energy intake (p<0.001). After adjusting for confounders, subjects regressed to normal values of HbA1c and increased their protein consumption (p=0.023). Before and after significance values were computed with paired t-test. Significances with covariate adjustment (age, age², sex, and BMI (in non-anthropometric variables)) were computed in a logistic regression model. BMI, body mass index; HbA1c, hemoglobin A1c; OGIS. Oral Glucose Insulin Sensitivity Index.