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. 2022 Oct 14;12(10):e060655. doi: 10.1136/bmjopen-2021-060655

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Pooled estimates of the safety outcomes comparing SGLT2 inhibitors with placebo. (A) Any serious adverse event, (B) discontinuation of the study drug due to adverse events, (C) amputation, (D) fracture, (E) volume depletion, (F) acute renal failure, (G) urinary tract infection and (H) genital infection, for comparisons between SGLT2 inhibitors and placebo. DAPA-CKD, Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease; DAPA-HF, Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure; EMPEROR-Preserved, Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction; EMPEROR-Reduced, Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction; RR, risk ratio; SGLT2, sodium-glucose cotransporter-2.