Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 2;21(10):e13696. doi: 10.1111/acel.13696

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Treatment effect on GrimAge age acceleration (AgeAccelGrim) and its components. (a) Grim AgeAccel is defined as the raw residuals derived from regression models of DNAmGrimAge on chronological age. (b–i) 8 GrimAge components: DNAm‐based estimators of (b) adrenomedullin (ADM), (c) beta‐2‐microglobulin (B2M), (d) cystatin C (cystatin C), (e) growth differentiation factor‐15 (GDF15), (f) leptin, (g) smoking pack‐years (PACKYRS), (h) PAI‐1 (PAI1), and (i) tissue inhibitor metalloproteinases 1 (TIMP1), respectively. Two‐sided uncorrected p‐values were derived from paired student's t‐tests