TABLE 1.

Top 20 DNA methylation sites significantly associated with the treatment

Chr	Probe	Bp	CpG island	Gene	Gene loc	Difference	CI_low	CI_high	p‐value	FDR
11	cg13824097	1,827,023				0.081	0.096	0.066	2.89E‐09	2.50E‐3
2	cg08357990	33,359,550		LTBP1	TSS200	−0.049	−0.039	−0.060	1.24E‐8	3.23E‐3
1	cg17034181	101,362,442	S_Shore	SLC30A7	Body	−0.047	−0.037	−0.056	1.41E‐8	3.23E‐3
16	cg11297013	8,346,717				0.025	0.031	0.020	1.49E‐8	3.23E‐3
6	cg03863838	36,562,081	Island	SFRS3	TSS200	−0.046	−0.036	−0.056	3.70E‐8	5.67E‐3
1	cg19081470	11,000,722				0.058	0.071	0.045	3.93E‐8	5.67E‐3
22	cg10695761	21,539,377	S_Shore			0.046	0.056	0.035	6.36E‐8	7.44E‐3
16	cg10765567	75,467,484	Island	CFDP1	TSS200	−0.003	−0.003	−0.004	6.87E‐8	7.44E‐3
7	cg05725489	600,658	N_Shore	PRKAR1B	Body	0.030	0.037	0.023	1.12E‐07	1.08E‐2
8	cg23628099	48,089,762				0.051	0.063	0.038	1.33E‐07	1.11E‐2
1	cg07907639	159,787,620				0.031	0.039	0.023	1.41E‐07	1.11E‐2
10	cg07834955	99,531,879	Island	SFRP5	TSS200	−0.006	−0.005	−0.008	1.63E‐07	1.13E‐2
3	cg26946032	129,305,723		PLXND1	Body	0.017	0.022	0.013	1.84E‐07	1.13E‐2
2	cg11865801	237,967,595				0.016	0.020	0.012	1.86E‐07	1.13E‐2
1	cg24710995	198,431,936				0.031	0.039	0.023	2.14E‐07	1.13E‐2
19	cg00772380	41,135,151	N_Shore	LTBP4	Body	0.025	0.031	0.019	2.19E‐07	1.13E‐2
5	cg00398767	109,037,023		MAN2A1	Body	0.034	0.043	0.026	2.22E‐07	1.13E‐2
20	cg22659862	57,438,238		GNAS	Body	0.012	0.014	0.009	2.36E‐07	1.13E‐2
9	cg09870092	80,938,588		PSAT1	Body	0.051	0.064	0.038	2.51E‐07	1.14E‐2
2	cg22708752	54,853,191	N_Shelf	SPTBN1	Body	0.005	0.007	0.004	2.78E‐07	1.20E‐2