Skip to main content
. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: J Med Chem. 2020 Sep 17;63(19):11054–11084. doi: 10.1021/acs.jmedchem.0c00996

Table 3.

In Vitro RBP4 and TTR Data for (±)-44 B-Region Analogues Bearing Alternative Substituted Aryl Head Groups

graphic file with name nihms-1842245-t0004.jpg
a

IC50 values for the SPA assay obtained in the presence of a fixed, 10 nM concentration of [3H]-all-trans-retinol.

b

IC50 values for the HTRF assay obtained in the presence of 1 μM concentration of all-trans-retinol.

c

IC50 values for the FP assay obtained in the presence of a fixed, 25 μM concentration of fluorescein isothiocyanate (FITC)-coupled TTR FP probe.

d

IC50 data is represented as the mean ± standard deviation or compounds tested more than twice the IC50 or as the mean of two independent experiments if only run twice. ND = not determined.