Table 5.

Comparison of TS and A4 concentrations at timepoints 1–5 in metyrapone- or osilodrostat-treated patients vs treatment-naïve CD patients or and vs controls. Values are presented as median (IQR).

Timepoint	TS (pmol/L)				A4 (pmol/L)
	Metyrapone		Osilodrostat		Metyrapone		Osilodrostat
	Values	P	Values	P	Values	P	Values	P
1
TP	68.0 (44.5)		32.0 (47.5)		322.0 (614.5)		234.0 (305.0)
Tn	32.4 (45.8)	0.5338	32.4 (45.8)	>0.9999	280.0 (216.0)	0.4389	280.0 (216.0)	>0.9999
C	30.7 (44.0)	0.4331	30.7 (44.0)	>0.9999	166.9 (137.8)	0.0391	166.9 (137.8)	>0.9999
2
TP	62.0 (58.0)		27.0 (31.5)		276.0 (696.0)		281.5 (150.3)
Tn	28.6 (55.6)	0.8627	28.6 (55.6)	>0.9999	208.9 (249.2)	0.4147	208.9 (249.2)	>0.9999
C	33.9 (51.7)	>0.9999	33.9 (51.7)	>0.9999	155.7 (167.7)	0.1199	155.7 (167.7)	0.9158
3
TP	65.5 (39.0)		28.0 (26.5)		697.5 (284.8)		195.0 (211.0)
Tn	20.2 (46.6)	0.2696	20.2 (46.6)	>0.9999	160.9 (184.4)	0.0148	160.9 (184.4)	>0.9999
C	27.1 (58.4)	0.8532	27.1 (58.4)	>0.9999	154.1 (194.9)	0.0109	154.1 (194.9)	>0.9999
4
TP	68.0 (33.5)		38.0 (44.0)		691.0 (751.0)		229.0 (192.0)
Tn	20.0 (39.2)	0.0382	20.0 (39.2)	>0.9999	179.1 (275.9)	0.0402	179.1 (275.9)	>0.9999
C	27.6 (55.4)	0.1512	27.6 (55.4)	>0.9999	116.9 (211.3)	0.0056	116.9 (211.3)	>0.9999
5
TP	61.5 (48.8)		30.0 (30.5)		370.0 (473.3)		182.0 (239.0)
Tn	28.3 (49.8)	0.3576	28.3 (49.8)	>0.9999	198.9 (289.1)	0.6719	198.9 (289.1)	>0.9999
C	32.7 (52.2)	0.5995	32.7 (52.2)	>0.9999	126.2 (112.6)	0.0866	126.2 (112.6)	>0.9999

C, controls; Tn, treatment-naïve CD patients; TP, metyrapone- or osilodrostat-treated patients.