TABLE 1.
IgG subclass responses to homologous LPS in plasma of cholera patients
| V. cholerae serotype | IgG subclass | GMTa (rangeb) | Fold increasec | Responder frequency (%)d | Pe |
|---|---|---|---|---|---|
| O1 | IgG1 | 393 (251–604) | 12.4 | 90 | <0.007 |
| IgG2 | 101 (42–240) | 20 | 90 | 0.009 | |
| IgG3 | 322 (214–467) | 6.6 | 80 | 0.009 | |
| IgG4 | 49 (32–75) | 6 | 80 | NS | |
| O139 | IgG1 | 676 (485–942) | 5 | 80 | 0.009 |
| IgG2 | 37 (28–50) | 9.4 | 70 | 0.03 | |
| IgG3 | 764 (586–916) | 5 | 90 | 0.002 | |
| IgG4 | 146 (92–231) | 2.5 | 60 | NS |
a
At 11 days after onset of disease.
b
GMT ± 1 SEM.
c
Increase of GMT at day 11 compared to that at the acute stage at day 2 after onset of disease.
d
Percentage showing a twofold increase in titer.
e
Statistical analyses (difference between titers at the acute stage and convalescence) were carried out by using the Wilcoxon signed rank test; P < 0.05 was considered significant.