TABLE 2.
IgA subclass responses to rCTB and homologous LPS in fecal extracts from cholera patients
| IgA subclass | Antigen | V. cholerae serotype | GMTa (rangeb) | Fold increasec | Responder frequencyd (no. of responders/total) | Pe |
|---|---|---|---|---|---|---|
| IgA1 | rCTB | O1 | 12 (8.4–16.8) | 7.7 | 75 (9/12) | NS |
| O139 | 5.4 (3.4–9.0) | 3.3 | 67 (9/13) | NS | ||
| LPS | O1 | 7.0 (4–12) | 2.7 | 67 (8/12) | NS | |
| O139 | 4.2 (3.2–5.6) | 2.3 | 67 (9/13) | 0.34 | ||
| IgA2 | rCTB | O1 | 22.0 (16–30) | 5.2 | 100 (12/12) | NS |
| O139 | 16.0 (10.4–23) | 5.2 | 75 (10/13) | 0.03 | ||
| LPS | O1 | 7.5 (6–10) | 2.5 | 67 (8/12) | NS | |
| O139 | 7.5 (4–15) | 2.0 | 55 (7/13) | NS |
a
GMT (specific titer/total IgA) at 11 days after onset of disease.
b
GMT ± 1 SEM.
c
Increase of GMT at day 11 compared to that at the acute stage at day 2 after onset of disease.
d
Percentage showing a twofold increase in titer.
e
Statistical analyses (difference between titers at the acute stage and convalescence) were carried out by using the Wilcoxon signed rank test; P < 0.05 was considered significant.