Table 2.
Influence of Adverse Reaction Variables on Spike Receptor-Binding Domain Immunoglobulin G Titer
| Reaction | Variable | No. (%) | GMT (95% CI), AU/mL | P Value | Fold Change, Mean (95% CI) | P Value |
|---|---|---|---|---|---|---|
| Local reactions | ||||||
| Pain at injection site | No | 3 (1.1) | 14 818 (4032–54 450) | .763 | 23.9 (10.9–52.4) | .618 |
| Yes | 278 (98.9) | 16 730 (15 413–18 155) | 29.2 (26.9–31.7) | |||
| Redness | No | 185 (65.8) | 16 761 (15 198–18 484) | .915 | 28.9 (26.2–31.9) | .734 |
| Yes | 96 (34.2) | 16 604 (14 328–19 244) | 29.7 (25.7–34.4) | |||
| Swelling | No | 148 (52.7) | 16 707 (14 866–18 772) | .998 | 30.5 (27.4–33.8) | .269 |
| Yes | 133 (47.3) | 16 707 (14 907–18 728) | 27.8 (24.5–31.6) | |||
| Systemic reactions | ||||||
| Fever | Absolute value | 281 (100) | r = 0.262a | <.001 | r = 0.082a | .170 |
| <37.0°C | 114 (40.6) | 14 011 (12 431–15 793) | <.001 | 26.9 (23.7–30.5) | .100 | |
| 37.0°C–37.9°C | 97 (34.5) | 16 302 (14 174–18 750) | 28.8 (25.3–32.9) | |||
| ≥38.0°C | 64 (24.9) | 23 020 (19 670–26 941) | 33.7 (28.1–40.5) | |||
| Fatigue | No | 42 (15.0) | 13 329 (10 713–16 581) | .022 | 26.2 (20.8–32.9) | .278 |
| Yes | 239 (85.1) | 17 382 (15 933–18 967) | 29.7 (27.2–32.4) | |||
| Headache | No | 94 (33.5) | 14 652 (12 885–16 661) | .024 | 29.3 (25.6–33.5) | .947 |
| Yes | 187 (66.6) | 17 848 (16 099–19 783) | 29.1 (26.3–32.3) | |||
| Chills | No | 135 (48.0) | 14 534 (13 077–16 151) | .001 | 27.3 (24.3–30.7) | .126 |
| Yes | 146 (52.0) | 19 006 (16 862–21 419) | 31.0 (27.6–34.8) | |||
| Vomiting | No | 272 (96.8) | 16 512 (15 198–17 943) | .121 | 29.1 (26.7–31.6) | .721 |
| Yes | 9 (3.2) | 23 752 (16 021–35 221) | 31.6 (22.5–44.5) | |||
| Diarrhea | No | 246 (87.5) | 16 811 (15 385–18 365) | .693 | 29.3 (26.8–32.0) | .812 |
| Yes | 35 (12.5) | 15 999 (13 005–19 683) | 28.4 (23.6–34.2) | |||
| Muscle pain | No | 40 (14.2) | 17 434 (14 142–21 493) | .674 | 28.9 (22.2–37.7) | .944 |
| Yes | 241 (85.8) | 16 588 (15 181–18 126) | 29.2 (26.8–31.8) | |||
| Joint pain | No | 128 (45.6) | 16 044 (14 315–17 980) | .370 | 27.9 (24.6–31.6) | .335 |
| Yes | 153 (54.5) | 17 282 (15 396–19 404) | 30.2 (27.1–33.7) | |||
| Lymphadenopathy | No | 194 (69.0) | 15 332 (13 845–16 975) | <.001 | 29.1 (26.1–32.4) | .956 |
| Yes | 87 (31.0) | 20 234 (17 857–22 935) | 29.2 (26.2–32.7) |
Abbreviations: CI, confidence interval; GMT, geometric mean titer.
a
r values refer to the Spearman correlation coefficient.