Table 3.
Influence of Antipyretics on Spike Receptor-Binding Domain Immunoglobulin G Titer and Fold Change After a Booster Dose
| Characteristic | No. (%) | GMT (95% CI) | P Value | Fold Change, Mean (95% CI) |
P Value | |
|---|---|---|---|---|---|---|
| Use of antipyretic medications | ||||||
| All participants | No | 162 (57.7) | 16 170 (14 601–17 906) | .357 | 28.9 (25.9–32.4) | .893 |
| Yes | 119 (42.4) | 17 466 (15 279–19 966) | 29.4 (26.1–33.2) | |||
| By fever grade | ||||||
| <37.0°C | No | 85 (74.6) | 14 217 (12 491–16 181) | .681 | 27.8 (23.8–32.4) | .400 |
| Yes | 29 (25.4) | 13 425 (10 006–18 009) | 24.6 (19.9–30.3) | |||
| 37.0°C–37.9°C | No | 50 (51.6) | 16 489 (13 602–19 985) | .869 | 30.0 (24.7–36.4) | .556 |
| Yes | 47 (48.5) | 16 106 (13 041–19 893) | 27.7 (23.2–33.2) | |||
| ≥38.0°C | No | 27 (38.6) | 23 388 (17 914–30 542) | .874 | 31.0 (22.4–42.8) | .465 |
| Yes | 43 (61.4) | 22 793 (18 612–27 906) | 35.6 (28.3–44.6) | |||
| Type of antipyretic | ||||||
| Only acetaminophen | … | 43 (36.1) | 17 132 (13 886–21 136) | Reference | 26.3 (21.3–32.5) | Reference |
| Only loxoprofen | … | 35 (29.4) | 14 820 (11 167–19 669) | .744 | 25.4 (2.6–31.2) | .991 |
| Only ibuprofen | … | 14 (11.8) | 20 306 (13 383–30 811) | .815 | 41.2 (28.5–59.7) | .068 |
| Othera | … | 27 (22.7) | 20 613 (15 651–27 149) | .637 | 35.9 (28.3–45.6) | .135 |
| Total dosage of antipyretic during 7-days after vaccination | ||||||
| Acetaminophen, mg, median (IQR) | 900 (400–1200) | r = 0.072b | .648 | r = .247b | .111 | |
| Loxoprofen, mg, median (IQR) | 120 (60–180) | r = 0.097b | .580 | r = .223b | .198 | |
| Ibuprofen, mg, median (IQR) | 200 (150–400) | r = –0.346b | .226 | r = –.201b | .491 | |
| Timing of antipyretic use | ||||||
| Antipyretic use on the day of vaccination | No | 108 (90.8) | 17 151 (14 856–19 797) | .398 | 30.0 (26.4–34.1) | .308 |
| Yes | 11 (9.2) | 20 903 (14 378–30 395) | 24.3 (16.9–34.9) | |||
Abbreviations: CI, confidence interval; GMT, geometric mean titer; IQR, interquartile range.
a
Including other type of antipyretics, combination drugs, or combination of several antipyretics.
b
r values refer to the Spearman correlation coefficient.