Table 5.
Spike Receptor-Binding Domain Immunoglobulin G Titers by the Presence or Absence of Fever After the Second and Booster Doses
| Fever ≥38.0°C After Vaccination (After Dose 2/Dose 3) | No. (%) | Female Sex, No. (%) | Age, y, Median (IQR) | 1 Month After Dose 2 | 8 Months After Dose 2 | 1 Month After Dose 3 | |||
|---|---|---|---|---|---|---|---|---|---|
| GMT (95% CI), AU/mL | P Value | GMT (95% CI), AU/mL | P Value | GMT (95% CI), AU/mL | P Value | ||||
| Absent/Absent | 110 (67.1) | 83 (75.5) | 42.0 (33.0–49.0) | 8281 (7305–9386) | Reference | 537 (474–607) | Reference | 15 438 (13 665–17 441) | Reference |
| Present/Absent | 12 (7.3) | 9 (75.0) | 33.5 (29.0–39.5) | 12 026 (8204–17 628) | .169 | 796 (552–1147) | 0.144 | 14 644 (10 630–20 174) | .990 |
| Absent/Present | 21 (12.8) | 12 (57.1) | 41.0 (46.0–51.0) | 9172 (6717–12 524) | .879 | 738 (515–1058) | 0.125 | 22 012 (16 555–29 270) | .060 |
| Present/Present | 21 (12.8) | 17 (81.0) | 40.0 (28.0–44.0) | 12 343 (9562–15 932) | .032 | 627 (481–817) | 0.682 | 22 479 (16 575–30 487) | .042 |
Abbreviations: CI, confidence interval; GMT, geometric mean titer; IQR, interquartile range.