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. 2022 Oct 18;41(3):111496. doi: 10.1016/j.celrep.2022.111496

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© 2022 The Authors

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Antibodies reactive to the S2 domain of seasonal betacoronaviruses are boosted upon SARS-CoV-2 infection and after vaccination to a lesser extent

(A and B) ELISAs were completed to determine the levels of S1- and S2-specific antibodies against spike of OC43, HKU1, and SARS-CoV after SARS-CoV-2 infection (A) or SARS-CoV-2 mRNA vaccination (B). Paired t tests or one-way ANOVA of log2-transformed antibody titers; ^∗∗∗∗p < 0.0001, ^∗∗∗p < 0.001, ^∗∗p < 0.01, ^∗p < 0.05. Data are representative of two independent experiments.

(C and D) Fold change of S1- and S2-specific antibodies was calculated before and after seroconversion and pre-/post-prime and boost mRNA vaccines. One-way ANOVA of antibody fold change; ^∗∗∗∗p < 0.0001, ^∗∗∗p < 0.001, ^∗∗p < 0.01.