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. 2022 Oct 18;41(3):111496. doi: 10.1016/j.celrep.2022.111496

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Seasonal coronavirus spike antibodies boosted by SARS-CoV-2 infection do not bind effectively to the SARS-CoV-2 spike

Sera samples from 10 SARS-CoV-2-infected health care workers and 10 SARS-CoV-2 mRNA-vaccinated participants were absorbed with SARS-CoV-2, OC43, HKU1, and 229E spike-coupled beads or mock-treated beads prior to antibody quantification by ELISA. We determined reciprocal antibody titers in samples before and after infection and pre-/post-the first dose of an mRNA vaccine for SARS-CoV-2, OC43, HKU1, 229E, and an unrelated antigen, influenza hemagglutinin H1.