Table 2.
Model base-case cohort characteristics
| Males (N = 690) | Females (N = 590) | |||||
|---|---|---|---|---|---|---|
| N (% of Total Cohort) | Mean Age (Years) | Mean eGFR (mL/min/ 1.73 m2) | N (% of Total Cohort) | Mean Age (Years) | Mean eGFR (mL/min/ 1.73 m2) | |
| CKD stage G1 | 222 (17.3%) | 33.6 | 105.9 | 225 (17.6%) | 34.5 | 105.8 |
| Subclass 1C | 89 (7.0%) | 37.7 | 105.0 | 103 (8.0%) | 38.6 | 102.9 |
| Subclass 1D | 83 (6.5%) | 33.1 | 102.9 | 80 (6.3%) | 33.8 | 107.3 |
| Subclass 1E | 50 (3.9%) | 27.0 | 112.4 | 42 (3.3%) | 26.0 | 109.8 |
| CKD stage G2 | 318 (24.8%) | 39.3 | 74.5 | 280 (21.9%) | 40.1 | 75.2 |
| Subclass 1C | 126 (9.8%) | 41.8 | 74.7 | 140 (10.9%) | 42.5 | 75.6 |
| Subclass 1D | 123 (9.6%) | 39.3 | 74.7 | 106 (8.3%) | 39.1 | 74.4 |
| Subclass 1E | 69 (5.4%) | 34.8 | 74.0 | 34 (2.7%) | 33.0 | 76.2 |
| CKD stage G3 | 150 (11.7%) | 41.3 | 50.8 | 85 (6.6%) | 41.7 | 52.0 |
| Subclass 1C | 37 (2.9%) | 44.9 | 52.1 | 34 (2.7%) | 44.6 | 52.5 |
| Subclass 1D | 66 (5.2%) | 41.7 | 51.7 | 34 (2.7%) | 41.7 | 51.2 |
| Subclass 1E | 47 (3.7%) | 37.9 | 48.5 | 17 (1.3%) | 35.8 | 52.4 |
Source: Otsuka, data on file (2018). Analysis of baseline data for 1280 typical, rapidly progressing patients enrolled in TEMPO 3:4, regardless of randomization to treatment or placebo
See Additional file 1: Table S1 for a description of CKD stages according to the KDIGO CKD staging system [20]
CKD Chronic kidney disease, eGFR Estimated glomerular filtration rate