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Paclitaxel and SMI#9 induce accumulation of tetraploid cells in S and G2/M phases. DNA content analyzed by flow cytometry after 24 and 48 h of treatment with PTX (5 nM for MDA-MB-468 and 10 nM for HCC1937 cells), SMI#9 (0.75 µM) or a combination of SMI#9 with the corresponding PTX dose. A, B MDA-MB-468 and (C, D) HCC1937 cells. B, D Percentage of cells in diploid and tetraploid G1, S and G2/M phases were estimated after analysis using Modfit software
