Table 2.
Grading of adverse event (AE) occurred in the 1st month*
| AE | Grade of AE in each patient | |||||
|---|---|---|---|---|---|---|
| P1 | P2 | P3 | P4 | P5 | P6 | |
| CRS | 1 | 1 | 1 | 1 | 0 | 1 |
| ICANS | 0 | 0 | 0 | 0 | 0 | 0 |
| Secondary infection | 0 | 0 | 0 | 0 | 0 | 0 |
| Hypoxia | 0 | 0 | 0 | 0 | 0 | 0 |
| Pulmonary edema | 0 | 0 | 0 | 0 | 0 | 0 |
| Hypotension | 0 | 0 | 0 | 0 | 0 | 2 |
| Nausea | 0 | 0 | 3 | 0 | 0 | 2 |
| Vomiting | 0 | 0 | 2 | 0 | 0 | 0 |
| Diarrhea | 0 | 2 | 2 | 2 | 0 | 2 |
| Oral mucositis | 0 | 2 | 0 | 0 | 0 | 0 |
| Purpura | 0 | 2 | 0 | 0 | 0 | 0 |
| Neutropenia | 3 | 3 | 3 | 3 | 3 | 3 |
| Anemia | 1 | 1 | 1 | 1 | 1 | 1 |
| Thrombocytopenia | 3 | 3 | 3 | 3 | 3 | 3 |
| Prolonged APTT | 0 | 0 | 1 | 0 | 0 | 1 |
| Hyperuricemia | 1 | 1 | 0 | 0 | 0 | 1 |
| Transaminitis | 1 | 1 | 0 | 1 | 1 | 1 |
| Hypoalbuminemia | 1 | 1 | 0 | 1 | 1 | 1 |
*Time calculated since CAR T-cell infusion
P patient, CRS cytokine release syndrome, ICANS immune effector cell associated neurotoxicity syndrome, APTT activated partial thromboplastin time