Figure 3:

Schematics showing the newly introduced methods to minimize the formation of biomolecular corona: (a) recruitment of proteins with natural targeting capacity through pre-coating of nanoparticles with specific protein(s); (b) minimizing the affinity of biomolecules to the surface of nanoparticles through specific coatings including zwitterionic compounds; and (c) using pre-adsorption, rather than chemical conjugation, of targeting species to the surface of nanoparticles. Copyright Nature Publishing Group 2018 [39].