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. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: Mol Imaging Biol. 2020 Oct 23;23(1):1–10. doi: 10.1007/s11307-020-01559-9

Figure 4.

Figure 4.

Development of protein corona sensor array for diagnostic purposes, (a) Scheme showing the formation of protein corona on the surface of multi-nanoparticles after interactions with patient plasmas to define “fingerprint” patterns specific to the diseases type, using advanced classifiers, (b-d) Use of two distinct supervised classifiers consisting of (b) partial least-squares discriminant analysis (PLS-DA) and (c,d) counter-propagation artificial neural network algorithm (CPANN) to analyze protein corona profiles for identification and separation of 5 distinct cancer types from each other and from healthy controls. Copyright 2019, Royal Society of Chemistry [85].