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. 2022 Sep 14;66(10):e00879-22. doi: 10.1128/aac.00879-22

FIG 6.

FIG 6

Morphologies of cells of K. pneumoniae, A. baumannii, and P. aeruginosa after treatment with xeruborbactam and control antibiotics. Klebsiella pneumoniae strain KPM1026a (A), Pseudomonas aeruginosa strain PAM1154 (B), and Acinetobacter baumannii strain ATCC 17978 (C) were treated with 1× and 2× MIC xeruborbactam for 1 and 2 h at 30°C. Meropenem, cephalexin, mecillinam (the USAN name amdinocillin is used in the text), and aztreonam were used as antibiotic controls. Cells were stained with FM4-64 (red, membrane stain), DAPI (blue, membrane-permeable DNA stain), and SYTOX green (green, membrane-impermeable DNA stain). Scale bar = 2 μm. The MICs for the tested strains were as follows. Strain KPM1026a measured at 30°C: xeruborbactam, 32 μg/mL; meropenem, 0.06 μg/mL; cephalexin, 128 μg/mL; and amdinocillin, 128 μg/mL. Strain PAM1154: xeruborbactam, 32 μg/mL; meropenem, 0.25 μg/mL; aztreonam, 0.25 μg/mL; and amdinocillin, 128 μg/mL. Strain ATCC 17978: xeruborbactam, 16 μg/mL; meropenem, 0.25 μg/mL; aztreonam, 32 μg/mL; and amdinocillin, 128 μg/mL.